. 2020 Jun 5;7:723–729. doi: 10.1016/j.toxrep.2020.06.001

Table 3.

Effect of hesperidin (125and250 mg/kg) and limonoids (50 and 100 mg/kg) AChE, Tau protein and β amyloid in brain homogenates of AD induced rats.

Group	Negative control (2 mL distilled water)	Positive control AlCl₃ (172 mg/kg)	Donepezil (0.75 mg/kg)	Hesperidin (125 mg/kg)	Hesperidin (250 mg/kg)	Limonoids (50 mg/kg)	Limonoids (100 mg/kg)
BiochemicalParameter	Negative control (2 mL distilled water)	Positive control AlCl₃ (172 mg/kg)	Donepezil (0.75 mg/kg)	Hesperidin (125 mg/kg)	Hesperidin (250 mg/kg)	Limonoids (50 mg/kg)	Limonoids (100 mg/kg)
Ach E (μ/mg protein)	29.84+2.22	76.13+4.29^@	47.7+2.36^@*	43.65+1.39^@*	42.18+2.17^@*	37+2.23*^&	51.28+2.02^@*
Tau protein (pg/mg protein)	7.4+0.74	90.6+ 3.13^@	42.85+2.1^@*	25.93+2.47^@*$&	24.28+1.43^@*$&	20.87+2.24^@*^$	52.8+2.37^@*
Beta-amyloid (ng/mg protein)	2.14+0.08	13.7+1.46^@	7.05+0.43^@*	5.57+0.45*	4.65+0.4*^&	4.59+0.25*^&	8.52+0.36^@*

Results are expressed as means of levels of AcH-E, Tau protein and βamyloid in brain tissue homogenates of rats ± SE, n = 10. significance at p < 0.05.@Significantly different from normal control *Significantly different from positive control.$ Significantly different from donepezil (0.75 mg/kg) group. & Significantly different from limonoids (100 mg/kg) group.