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. 2020 Apr 4;47(3):219–228. doi: 10.1007/s10928-020-09682-4

Table 1.

Statistics on the termination of parameter uncertainty determination by method

Method Number of terminations (n = 1000 simulations)
Subjects in dataset 5 10 50
SE 31 1 0
BSa (mean, 5th, 95th percentile) 3.1 (0, 17) 0.09 (0, 1) 0.002 (0, 0)
LLP 0 0 0
SE-SIRb 0 0 0
BS-SIR 8 0 0
LLP-SIR 2 0 0
MCMC 0 0 0
NUTS 0 0 0

aTerminated runs per n = 1000 BS over 1000 simulations

bProposal distribution was SE in 969 simulations and educated guess in 31 simulations, where covariance step failed