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. 2020 Jun 11;10:9450. doi: 10.1038/s41598-020-65317-1

Table 2.

Comparison of odds ratios and allele frequencies between Indians and Europeans. 95% confidence intervals shown in brackets. P value for comparison of odds ratios.

Indians Europeans
OR T1D CONT OR T1D CONT P
DR3/DR4 49.2 0.14 0.01 51.3 0.34 0.03 0.95
14.0–172.2) (38.6–68.1)
DR4/DR4 3.6 0.02 0.02 18.7 0.06 0.01 0.02
(0.9–13.9) (12.4–28.0)
DR3/DR3 148.8 0.27 0 16.9 0.09 0.02 0.04
(19.5–1136.2) (12.0–23.8)
DR4/X 6.3 0.18 0.11 6.9 0.26 0.17 0.79
(3.4–11.4) (5.6–8.4)
DR3/X 8.3 0.27 0.10 3.4 0.15 0.21 0.004
(4.7–14.5) (2.7–4.2)
any DR3 9.6 0.56 0.12 4 0.58 0.26 0.0001
(6.2–14.9) (3.6–4.5)
any DR4 3.2 0.34 0.14 7 0.66 0.21 0.0005
(2.1–4.9) (6.2–8.0)
rs3129889 (HLA-DRB1*15) 0 1 0.99 9.1 0.99 0.86 XX
(0-0.76) (6.4–13.0)
rs2395029 (HLA-B*5701) 1.1 0.98 0.96 2.9 0.99 0.96 0.07
(0.4–2.9) (1.9–4.2)
rs2476601 (PTPN22) 1.8 0.02 0.01 2.1 0.17 0.1 0.79
(0.5–6.4) (1.8–2.5)
rs689 (INS) 2.8 0.94 0.86 1.6 0.80 0.7 0.72
(1.6–5.1) (1.4–1.8)
rs12722495 (IL2RA) 1.3 0.95 0.95 1.5 0.92 0.89 0.61
(0.6–2.5) (1.25–1.8)
rs1264813 (HLA-A*24) 1.4 0.19 0.17 1.6 0.13 0.1 0.62
(0.9–2.1) (1.3–1.9)
rs2292239 (ERBB3) 1.5 0.31 0.24 1.4 0.40 0.34 0.7
(1.0–2.1) (1.2–1.5)