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. 2020 Jun 11;10:9477. doi: 10.1038/s41598-020-66373-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Determination of the size of Aβ oligomers within the pearl necklace-like assemblies. (a) Image taken before single molecule photobleaching experiment after 2 hr incubation; (b) image taken after complete photobleaching and then another incubation for 12 hr. Scale bars are 10 µm for both a,b; (c) A localization map for all monomers and oligomer detected in the highlighted assembly; (d) Exemplar photobleaching profiles for monomer, dimer, trimer, and tetramer; (e) Size distribution of Aβ oligomers with PIF software version 1.1.2 (http://www.biophys.umontreal.ca/bluncklab/software.html) analysis of images taken from 2 hr incubation (Red) and after complete photobleaching and 12 hr incubation for the same areas (Blue).