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. 2020 Jun 11;10:9477. doi: 10.1038/s41598-020-66373-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Proposed mechanism of Aβ monomer/oligomer attachment to two different lipid membranes, POPC (a) and DLPC (b). In this model, Aβ insertion into the membrane is energetically more favourable for DLPC as it relieves the mechanical strain caused by the highly curved regions of the membrane patches, which in turn promotes Aβ aggregation by enhancing its local concentration. The shape of the Aβ assemblies resembles that of the membrane patches. Aβ oligomers coloured in brown interact with defects on the edges of multiple bilayers of DLPC which create hotspots for Aβ attachment.