Table 2.

Novel CCT loci identified in the combined (GERA+IGGC) GWAS meta-analysis.

					Combined meta-analysis				GERA		IGGC
SNV	Chr	Pos	Locus	Alleles	β (SE)	P	Q	I	β (SE)	P	β (SE)	P
rs10800558	1	170828021	PRRX1	C/A	1.38 (0.24)	6.6 × 10−9	0.30	6.67	1.09 (0.37)	0.0029	1.59 (0.31)	3.7 × 10−7
rs848546	2	36704767	CRIM1	A/G	−1.55 (0.25)	5.4 × 10−10	0.37	0	−1.81 (0.39)	2.9 × 10−6	−1.36 (0.33)	3.0 × 10−5
rs1800440	2	38298139	CYP1B1	T/C	−1.89 (0.33)	1.4 × 10−8	0.88	0	−1.83 (0.50)	0.00026	−1.93 (0.44)	1.4 × 10−5
rs880930	2	238396872	MLPH	G/C	1.58 (0.29)	2.7 × 10−8	0.34	0	1.26 (0.44)	0.0040	1.82 (0.37)	1.2 × 10−6
rs11917483	3	29393868	RBMS3	T/C	−1.66 (0.26)	1.2 × 10−10	0.92	0	−1.63 (0.39)	2.5 × 10−5	−1.68 (0.35)	1.1 × 10−6
rs62292788	3	187016877	LOC101929130	G/A	1.56 (0.25)	2.9 × 10−10	0.17	48.13	1.97 (0.38)	3.2 × 10−7	1.27 (0.32)	8.1 × 10−5
rs2320163	4	140174641	MGARP	G/C	1.59 (0.24)	3.7 × 10−11	0.94	0	1.57 (0.37)	2.0 × 10−5	1.61 (0.32)	4.3 × 10−7
rs7737693	5	52602941	FST	C/T	1.40 (0.25)	1.3 × 10−8	0.49	0	1.21 (0.37)	0.0011	1.54 (0.33)	2.4 × 10−6
rs35351529	5	79390222	THBS4	T/C	2.43 (0.44)	3.2 × 10−8	0.18	43.25	3.05 (0.64)	2.1 × 10−6	1.88 (0.60)	0.0017
rs2731646	5	121420919	LOX	A/G	1.73 (0.24)	5.2 × 10−13	0.92	0	1.76 (0.37)	1.5 × 10−6	1.71 (0.32)	7.2 × 10−8
rs154001	5	127685135	FBN2	C/T	1.54 (0.27)	8.8 × 10−9	0.067	70.21	2.08 (0.40)	1.9 × 10−7	1.10 (0.36)	0.0022
rs6459472	6	16522607	ATXN1	A/G	1.45 (0.24)	2.6 × 10−9	0.17	47.74	1.06 (0.37)	0.0040	1.74 (0.32)	6.7 × 10−8
rs9350413	6	22067279	LINC00340	T/A	−1.42 (0.25)	2.5 × 10−8	0.76	0	−1.51 (0.38)	6.9 × 10−5	−1.35 (0.35)	9.3 × 10−5
rs7749695	6	113376787	RFPL4B	T/C	1.48 (0.27)	2.7 × 10−8	0.40	0	1.76 (0.42)	2.8 × 10−5	1.30 (0.35)	0.00017
rs10124621	9	111488128	ACTL7B	G/T	−1.61 (0.27)	1.9 × 10−9	0.54	0	−1.79 (0.40)	7.5 × 10−6	−1.46 (0.36)	5.1 × 10−5
rs4623781	10	25803024	GPR158	A/T	1.35 (0.24)	1.3 × 10−8	0.45	0	1.13 (0.37)	0.0021	1.50 (0.31)	1.2 × 10−6
rs2505507	10	43644824	CSGALNACT2	C/T	1.53 (0.27)	2.1 × 10−8	0.27	18.15	1.87 (0.41)	5.7 × 10−6	1.26 (0.36)	0.00051
rs4311997	10	124179299	PLEKHA1	C/T	1.35 (0.23)	8.3 × 10−9	0.85	0	1.40 (0.36)	0.00011	1.31 (0.31)	1.9 × 10−5
rs688601	11	1891284	LSP1	T/A	−1.67 (0.30)	2.7 × 10−8	0.55	0	−1.92 (0.51)	0.00019	−1.54 (0.37)	3.3 × 10−5
rs3740685	11	47468791	RAPSN	C/T	1.50 (0.26)	5.7 × 10−9	0.77	0	1.59 (0.40)	6.0 × 10−5	1.44 (0.34)	2.3 × 10−5
rs4611262	12	102502759	NUP37	T/C	2.37 (0.30)	2.0 × 10−15	0.21	35.97	2.80 (0.45)	6.2 × 10−10	2.05 (0.40)	2.7 × 10−7
rs1176321	13	81227243	SPRY2	G/A	1.77 (0.26)	9.3 × 10−12	0.85	0	1.83 (0.39)	2.9 × 10−6	1.73 (0.35)	7.0 × 10−7
rs28667150	14	73137234	DPF3	G/A	−1.64 (0.25)	5.3 × 10−11	0.52	0	−1.83 (0.38)	1.5 × 10−6	−1.50 (0.33)	6.6 × 10−6
rs12898341	15	51456385	MIR4713HG	C/T	−1.59 (0.24)	4.2 × 10−11	0.42	0	−1.82 (0.37)	7.7 × 10−7	−1.43 (0.32)	9.0 × 10−6
rs12324079	15	79501867	ANKRD34C−AS1	T/G	−1.54 (0.24)	2.0 × 10−10	0.65	0	−1.67 (0.37)	7.0 × 10−6	−1.44 (0.32)	6.2 × 10−6
rs4785955	16	4297651	LOC100507501	G/T	1.79 (0.30)	3.3 × 10−9	0.50	0	1.57 (0.45)	0.00049	1.98 (0.41)	1.4 × 10−6
rs7211723	17	63854425	CEP112	A/C	−1.62 (0.27)	3.4 × 10−9	0.63	0	−1.77 (0.42)	2.7 × 10−5	−1.50 (0.36)	2.8 × 10−5
rs448203	17	75495065	SEPT9	T/C	1.84 (0.29)	2.1 × 10−10	0.54	0	2.01 (0.41)	7.8 × 10−7	1.66 (0.41)	5.3 × 10−5
rs11650127	17	79572253	NPLOC4	G/A	−1.96 (0.30)	4.8 × 10−11	0.49	0	−2.15 (0.40)	1.1 × 10−7	−1.73 (0.44)	8.1 × 10−5
rs13036662	20	2784053	CPXM1	G/A	−2.11 (0.38)	3.2 × 10−8	0.73	0	−1.95 (0.60)	0.0012	−2.22 (0.49)	6.8 × 10−6
21:40195541	21	40195541	ETS2	G/GT	1.46 (0.25)	7.2 × 10−9	0.27	18.75	1.78 (0.38)	3.0 × 10−6	1.22 (0.34)	0.00033