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. 2020 Jun 11;10:9457. doi: 10.1038/s41598-020-66320-2

Table 4.

Costs of the contingent models.

1/1000 ≤ intermediate risk < 1/50 cFTS quadruple screening triple screening double screening
n or % USD n or % USD n or % USD n or % USD
DR of T21(%) 87.88 90.91 84.62 91.67
diagnosis 124 47740 63 24255 68 26180 590 227150
NIPS 983 362727 845 311805 1296 478224 10846 4002174
missed detection for T21 4 738460 1 184615 2 369230 5 923075
screening 21713 1020511 8087 372002 13692 479220 68512 1575776
overall cost 2169438 892677 1352854 6728175
average cost per DS detected 74808 89268 122987 122330
1/1500 ≤ intermediate risk < 1/50
DR of T21(%) 93.94 90.91 84.62 91.67
diagnosis 126 48510 65 25025 71 27335 612 235620
NIPS 1458 538002 1146 422874 1781 657189 15169 5597361
missed detection for T21 2 369230 1 184615 2 369230 3 553845
screening 21713 1020511 8087 372002 13692 479220 68512 1575776
overall cost 1976253 1004516 1532974 7962602
average cost per DS detected 63750 100452 139361 139695
1/2000 ≤ intermediate risk < 1/50
DR of T21(%) 93.94 90.91 84.62 98.33
diagnosis 128 49280 66 25410 73 28105 633 243705
NIPS 1898 700362 1426 526194 2200 811800 19413 7163397
missed detection for T21 2 369230 1 184615 2 369230 1 184615
screening 21713 1020511 8087 372002 13692 479220 68512 1575776
overall cost 2139383 1108221 1688355 9167493
average cost per DS detected 69012 110822 153487 155381
1/1000 ≤ intermediate risk < 1/100
DR of T21(%) 87.88 90.91 84.62 91.67
diagnosis 190 73150 129 49665 155 59675 1455 560175
NIPS 917 338373 779 287451 1209 446121 9977 3681513
missed detection for T21 4 738460 1 184615 2 369230 5 923075
screening 21713 1020511 8087 372002 13692 479220 68512 1575776
overall cost 2170494 893733 1354246 6740539
average cost per DS detected 74845 89373 123113 122555
1/1500 ≤ intermediate risk < 1/100
DR of T21(%) 93.94 90.91 84.62 91.67
diagnosis 192 73920 130 50050 157 60445 1477 568645
NIPS 1392 513648 1080 398520 1694 625086 14300 5276700
missed detection for T21 2 369230 1 184615 2 369230 3 553845
screening 21713 1020511 8087 372002 13692 479220 68512 1575776
overall cost 1977309 1005187 1533981 7974966
average cost per DS detected 63784 100519 139453 139912
1/2000 ≤ intermediate risk < 1/100
DR of T21(%) 93.94 90.91 84.62 98.33
diagnosis 194 74690 132 50820 160 61600 1496 575960
NIPS 1832 676008 1360 501840 2113 779697 18274 6743106
missed detection for T21 2 369230 1 184615 2 369230 1 184615
screening 21713 1020511 8087 372002 13692 479220 68512 1575776
overall cost 2140439 1109277 1689747 9079457
average cost per DS detected 69046 110928 153613 153889
1/1000 ≤ intermediate risk<1/270
DR of T21(%) 87.88 90.91 84.62 91.67
diagnosis 374 143990 309 118965 420 161700 3668 1412180
NIPS 732 270108 598 220662 943 347967 7753 2860857
missed detection for T21 4 738460 1 184615 2 369230 5 923075
screening 21713 1020511 8087 372002 13692 479220 68512 1575776
overall cost 2173069 896244 1358117 6771888
average cost per DS detected 74933 89624 123465 123125
1/1500 ≤ intermediate risk < 1/270
DR of T21(%) 93.94 90.91 84.62 91.67
diagnosis 376 144760 310 119350 422 162470 3689 1420265
NIPS 1207 445383 899 331731 1428 526932 12076 4456044
missed detection for T21 2 369230 1 184615 2 369230 3 553845
screening 21713 1020511 8087 372002 13692 479220 68512 1575776
overall cost 1979884 1007698 1537852 8005930
average cost per DS detected 63867 100770 139805 140455
1/2000 ≤ intermediate risk < 1/270
DR of T21(%) 93.94 90.91 84.62 98.33
diagnosis 378 145530 312 120120 424 163240 3709 1427965
NIPS 1647 607743 1179 435051 1847 681543 16050 5922450
missed detection for T21 2 369230 1 184615 2 369230 1 184615
screening 21713 1020511 8087 372002 13692 479220 68512 1575776
overall cost 2143014 1111788 1693233 9110806
average cost per DS detected 69129 111179 153930 154420

*The screening results were calculated independently.