Table 1.
Clinical Characterisation of the enrolled participants.
| Characteristics | Patients (n = 23) | Controls (n = 11) | |
|---|---|---|---|
| Age (years) | 65 ± 11(41–80) | 58 ± 12(54–71) | |
| Age of Diagnosis (years) | 59 ± 9.7(40–69) | — | |
| Length of Diagnosis (years) | 11.7 ± 6.3(40–69) | — | |
| Male:Female | 12:11 | 6:5 | |
| SARA | 1. Gait (0–8) | 2.6 ± 1.8 (1–7) | — |
| 2. Stance (0–6) | 1.7 ± 1.1 (0–4) | — | |
| 3. Sitting (0–4) | 1.1 ± 1.2 (0–4) | — | |
| 4. Speech Disturbance (0–6) | 1.2 ± 1.2 (0–3) | — | |
| 5. Finger Chase (L) (0–4) | 1.3 ± 0.8 (0–2) | — | |
| 5. Finger Chase (R) (0–4) | 1. ±–0.7 (0–2) | — | |
| 6. Nose-finger test (L) (0–4) | 0. ±–0.8 (0–3) | — | |
| 6. Nose–finger test (R) (0–4) | 0.9 ± 0.9 (0–3) | — | |
| 7. Fast alternating hand movements (L)(0–4) | 1.2 ± 1 (0–3) | — | |
| 7. Fast alternating hand movements (R)(0–4) | 0.9 ± 1 (0–3) | — | |
| 8. Heel-Shin Slide (L) (0–4) | 0.8 ± 0.8 (0–2) | — | |
| 8. Heel-Shin Slide (R) (0–4) | 0.9 ± 0.7 (0–2) | — | |
| Total SARA (0–40) | 11 ± 6.7 (0–27) | — | |
| *Phenotypes | Pure (central) CA | 12 | — |
| CABV | 4 | — | |
| CABV + SS | 7 | — | |
Captions: n: number of participants, CA: Cerebellar Ataxia,
L: Left, R: Right, Data presented as mean ± standard deviation,
CABV: Cerebellar Ataxia with Bilateral Vestibulopathy, SS: Somatosensory.
*Deep phenotyping has not been undertaken in these subjects.