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. 2020 Jun 11;11:2968. doi: 10.1038/s41467-020-16798-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a, b Groups of C57BL/6J (n = 6 for mock, n = 8 for MNV-1, n = 6 for MNV-3, n = 8 for MNV-CR6) or C57BL/6J-Ifnar^−/− (n = 6 for mock, n = 8 for MNV-1, n = 7 for MNV-3, n = 7 for MNV-CR6) mice were perorally infected with 10⁷ TCID₅₀ units of MNV-1 (blue), MNV-3 (red), MNV-CR6 (green), or mock (black) inoculum and followed for weight loss (a) and survival (b). c Representative images of fecal samples indicating each score used to assess for diarrhea are shown. d, e Groups of 3-day-old BALB/c pups were infected with 10⁸ TCID₅₀ units of MNV-1 (blue), UV-inactivated MNV-1 (white with blue border), MNV-3 (red), MNV-CR6 (green), or mock (black) inoculum by oral gavage. Pups (n = 19 for mock, n = 21 for MNV-1, n = 9 for UV-inactivated MNV-1, n = 21 for MNV-3, n = 19 for MNV-CR6) were monitored for fecal consistency by palpating their abdomens (d). The proportion of mice scoring a 3 or 4 at any time point over the 5 days course of infection is presented as the incidence of diarrhea (e). Error bars denote standard errors of mean in all figures. P values were determined using two-way ANOVA with corrections for multiple comparisons. Source data are provided as a Source data file.