Fig. 6. MNV-1 infected Rag1−/− pups show decreased diarrhea but increased viral titers.
a Groups of 3-day-old BALB/c-Rag1−/− pups (blue stripes) were infected with 108 TCID50 units MNV-1 by oral gavage. At 2 dpi (n = 15), total viral titers were determined in the indicated segments of the intestinal tract and spleen by plaque assay, and compared with those of wild-type BALB/c pups (solid blue). b, c Additional BALB/c-Rag1−/− pups (n = 16, open circles) were infected with 108 TCID50 units MNV-1 by oral gavage and monitored for fecal consistency over a 5-day time course by palpating their abdomens. Fecal scores (b) and diarrhea incidence (c) were compared with those in wild-type BALB/c pups (solid blue). Error bars denote standard errors of mean in all figures. P values were determined using two-way ANOVA with corrections for multiple comparisons for viral titers. For incidence, P values were determined using a Mantel-Cox test. Source data are provided as a Source data file.