TABLE 1.

Overview of studies examining the involvement of key histone modifying enzymes and histone variants in zebrafish development.

Epigenetic factors		Developmental processes	References
Histone modifiers	CMLO3	Axis elongation and head formation	Karmodiya et al., 2014
	HDAC1	Craniofacial development, neurogenesis, retinal differentiation, inner hear development, liver, and pancreas morphogenesis	Cunliffe, 2004; Stadler et al., 2005; Yamaguchi et al., 2005; Noël et al., 2008; Zhou et al., 2011; Ignatius et al., 2013; He et al., 2016a
	HDAC3	Liver and posterior lateral line development	Farooq et al., 2008; He et al., 2016b
	HDAC4	Perichondral ossification and pharyngeal skeleton development	DeLaurier et al., 2019
	HDAC5*	Cardiac valve formation	Just et al., 2011
	HDACs	Cardiac valve formation	Kim et al., 2012
	JMJD3	Myelopoiesis	Yu et al., 2018
	KAT2a and b	Craniofacial development	Sen et al., 2018
	KAT7	Angiogenesis	Yan et al., 2018
	KDM6ba	Brain, craniofacial, and heart development	Van Laarhoven et al., 2015; Akerberg et al., 2017
	KDM7	Brain development	Tsukada et al., 2010
	KMT2A	Neurogenesis	Huang et al., 2015
	KMT2D	Brain, craniofacial, and heart development	Van Laarhoven et al., 2015
	LSD1	Brain development Haematopoiesis	Li et al., 2012; Takeuchi et al., 2015
	MOZ	Pharyngeal segmentation	Miller et al., 2004
	PHF8	Brain and craniofacial development	Qi et al., 2010
	PRDM3 and 16	Craniofacial development	Shull et al., 2020
	PRMT1	Gastrulation movements	Tsai et al., 2011
	PRMT5	Germline differentiation	Zhu et al., 2019
	PRMT6	Gastrulation movements	Zhao et al., 2016
	SETDB2	Gastrulation movements	Du et al., 2014
	SET7/9	Myoblast differentiation	Tao et al., 2011
	SETD7	Heart morphogenesis	Kim et al., 2015
	SMYD3	Cardiac and skeletal muscle development	Fujii et al., 2011; Kim et al., 2015
	SMYD4	Heart morphogenesis	Xiao et al., 2018
	SMYD5	Haematopoiesis	Fujii et al., 2016
Histone variants	H2Af1o	Cell synchrony division before mid-blastula transition	Yue et al., 2013
	H2A.FV	Early embryogenesis	Sivasubbu et al., 2006; Madakashira et al., 2017; Murphy et al., 2018
	H2A.Z.2	Melanocyte differentiation	Raja et al., 2020
	H3.3	Cranial neural crest differentiation	Cox et al., 2012
	macroH2A1 and 2	Brain, somite, and fin development	Buschbeck et al., 2009; Gonzalez-Munoz et al., 2019

* Inactivation of HDAC5 is required during cardiac valve formation.