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hIL-22 secreted by PRB782 induces production of the antimicrobial peptide Reg3α in human enteroids. Reg3α present in enteroids supernatants treated with PRB484, PRB782, and pRB577. Monolayer of enteroids were treated for 16 h and detection of Reg3α was done by ELISA. Data represent the average of six biological replicates. Error bars indicate the standard deviation of the mean. Comparisons performed with analysis of variance (ANOVA) (multiple groups). ****P < 0.0001.
