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. 2020 Jun 5;13:103. doi: 10.3389/fnmol.2020.00103

FIGURE 1.

FIGURE 1

The inverse relation between SG formation and ischemic injury in ischemic cortex of MCAO rats. (A) Infarct volume was the greatest after 24 h of reperfusion in the MCAO model. TTC staining was used to measure infarct size (n = 72 rats, 12 rats/group). (B) The most severe brain injury appeared at 24 h post-reperfusion. (C) Apoptosis levels were elevated in the ischemic cortices of MCAO rats after 24 h of reperfusion. Green color represents apoptotic cells, and blue color represents DAPI staining for the nucleus. (D) SG formation was increased in the MCAO model after 0 and 6 h of reperfusion. SG labeled with TIA1 (green), G3BP1 (red), and DAPI (blue). Scale bars: 10 and 25 μm. SG, stress granules; MCAO, middle cerebral artery occlusion. **P value < 0.01; ****P value < 0.0001.