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. 2020 Jun 5;11:815. doi: 10.3389/fphar.2020.00815

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Copyright © 2020 Li, Li, Wang, Zhao, Yang, Niu, Yang, Zheng, Hu and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of SMI on DOX-induced cardiac injury in mice. (A) Survival curves (n = 12 for the control group, n = 20 for the other groups). (B, C) The levels of CK and CK-MB in serum (n = 12 for the control group, n = 8 for the DOX injury group, n = 16 for the SMI treatment group, n = 18 for the DRZ treatment group). (D) HE staining of myocardial sections. Immune cells are marked with short arrows. (E) WGA staining of myocardial sections (n = 3). Ventricular cardiomyocyte cross-sectional area measurements (right). The value represents the mean ± SD. ^*P < 0.05, ^**P < 0.01 vs. control group, ^##P < 0.01 vs. DOX injury group.