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Theoretical model of biomarker changes throughout MCI. Aβ may be most relevant to clinical status in early and middle MCI, plateauing in later stages. Phosphorylated tau, neurodegeneration, and synaptic dysfunction may not exert clinical effects until late MCI. NFL elevations are consistent across all MCI stages. Aβ, amyloid beta; MCI, mild cognitive impairment; NC, normal cognition; NFL, neurofilament light; P-tau, phosphorylated tau; T-tau, total tau.
