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. 2020 Jun 5;11:821. doi: 10.3389/fphar.2020.00821

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Copyright © 2020 Zhao, Wang, Gao, Jing and Xin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Berberine increased the capability of Langendorff-perfused isolated rat hearts for contraction. (A) An original recording showing that the effect of berberine on left ventricular pressure (LVP) of an isolated rat heart. (B–D) Summary data showing the effects of berberine on LVDP, +dp/dt_max and |−dp/dt|_max, respectively. The numbers of repeats are as follows: vehicle control group, N = 6; Ber-treated group, N = 6; N is the number of rats. Ber stands for berberine. *p < 0.05, **p < 0.01 vs. vehicle control group; two-way ANOVA with Sidak's multiple comparisons test.