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. 2020 Jun 5;11:821. doi: 10.3389/fphar.2020.00821

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Copyright © 2020 Zhao, Wang, Gao, Jing and Xin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Berberine increased the tension of the freshly isolated left ventricular muscle (LVM) strips pretreated with epinephrine. (A, B) Original isometric tension recordings showing that berberine (100 µM) increased the tension and abolished the epinephrine-evoked phasic contractions in LVM strips. (C) Summary data showing that the effect of berberine on the tension of the LVM strips pretreated with epinephrine. The numbers of repeats are as follows: 30 µM and 50 µM Ber, n = 7, N = 7; 100 µM Ber, n = 8, N = 8; n and N are the numbers of LVM strips and rats, respectively. Ber stands for berberine. ***p < 0.001 vs. vehicle control group; two-way ANOVA with Sidak's multiple comparisons test.