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. 2020 Jun 5;11:821. doi: 10.3389/fphar.2020.00821

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Copyright © 2020 Zhao, Wang, Gao, Jing and Xin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Berberine increased the tension of the electrical field stimulation (EFS)-paced left ventricular muscle (LVM) strips. (A, B) Original isometric tension recordings showing that berberine (100 µM) increased the tension of the EFS-paced LVM strips (5 V, 1 Hz). (C) Summary data indicating that berberine increases the tension of the EFS-paced LVM strips in a concentration-dependent manner. The numbers of repeats are as follows: 30 µM Ber, n = 5, N = 5; 50 µM Ber, n = 8, N = 8; 100 µM Ber, n = 6, N = 6; 200 µM Ber and 300 µM Ber, n = 7, N = 7; n and N are the numbers of LVM strips and rats, respectively. Ber stands for berberine. ***p < 0.001 vs. vehicle control group; two-way ANOVA with Sidak's multiple comparisons test.