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. 2020 Jun 5;11:821. doi: 10.3389/fphar.2020.00821

Figure 5.

Figure 5

Berberine concentration-dependently increased the intracellular Ca2+ level of freshly isolated left ventricular (LV) myocytes. (A, B) Original Ca2+ imaging recordings showing that berberine (100 µM) increased the intracellular Ca2+ level of freshly isolated LV myocytes. (C) Summary data showing that berberine concentration-dependently increased the intracellular Ca2+ level. The numbers of repeats are as follows: 30 µM Ber, n = 54, N = 3; 50 µM Ber, n = 65, N = 3; 100 µM Ber, n = 35, N = 3; 300 µM Ber, n = 36, N = 3; n and N are the numbers of LV myocytes and rats, respectively. Ber stands for berberine. *p < 0.05, ***p < 0.001 vs. vehicle control group; two-way ANOVA with Sidak's multiple comparisons test.