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. 2020 Jun 5;11:821. doi: 10.3389/fphar.2020.00821

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Copyright © 2020 Zhao, Wang, Gao, Jing and Xin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Nifedipine attenuated the berberine-induced tension increase in left ventricular muscle (LVM) strips. (A–D) Original isometric tension recordings of the LVM strips treated with vehicle (A), 300 μM Ber (B), 10 μM nifedipine (C), and 300 μM Ber in the presence of 10 μM nifedipine (D), respectively. (E) Summary data showing nifedipine hindered the 300 μM berberine-induced tension increase in LVM strips. The numbers of repeats are as follows: vehicle control of 300 µM Ber, n = 6, N = 6; 300 µM Ber, n = 6, N = 6; 10 μM nifedipine, n = 7, N = 7; 300 µM Ber plus 10 μM nifedipine, n = 5, N = 5; n and N are the numbers of LVM strips and rats, respectively. Ber stands for berberine. ***p < 0.001 vs. vehicle control group; ^#p < 0.05, vs. 300 μM Ber-treated group; two-way ANOVA with Tukey's multiple comparisons test.