Figure 8.

Berberine increased the tension of the freshly isolated left ventricular muscle (LVM) strips pretreated with FPL-64716. (A, B) Original isometric tension recordings of the LVM strips treated with 10 µM FPL-64716 (A) and 300 μM berberine in the presence of 10 µM FPL-64716 (B). (C) Summary data showing berberine induced an additional increase in the tension of the LVM strips pretreated with FPL-64716. The numbers of repeats are as follows: 10 µM FPL-64716, n = 4, N = 3; 300 µM Ber plus 10 μM FPL-64716, n = 3, N = 3; n and N are the numbers of LVM strips and rats, respectively. Ber stands for berberine. *p < 0.05 vs. 10 µM FPL-64716-treated group; two-tailed unpaired Student's t-test.