Table 1.
The minor allele frequencies of SLCO1B1 c.388A>G (rs2306283) and c.521T>C (rs4149056) and the observed frequencies for selected SLCO1B1 haplotypes in Thais distributed among the five regions of Thailand.
| SLCO1B1 | Total | Northern | Central | Northeastern | Southern | Bangkok | p-value |
|---|---|---|---|---|---|---|---|
| Minor allele frequencies | |||||||
| N | 1,205 | 279 | 318 | 379 | 159 | 70 | |
| c.388A>G | 0.782 | 0.805 | 0.769 | 0.792 | 0.755 | 0.757 | 0.328 |
| c.521T>C | 0.129 | 0.120 | 0.143 | 0.137 | 0.085 | 0.150 | 0.090 |
| Haplotype frequencies (%) | |||||||
| N | 2,410 | 558 | 636 | 758 | 318 | 140 | |
| *1a a | 21.74 | 19.53 | 22.96 | 20.84 | 24.21 | 24.29 | 0.382 |
| *1b b | 65.39 | 68.46 | 62.74 | 65.44 | 67.30 | 60.71 | 0.187 |
| *5 c | 0.08 | 0.00 | 0.16 | 0.00 | 0.31 | 0.00 | 0.450 |
| *15 d | 12.78 | 12.01 | 14.15 | 13.72 | 8.18 | 15.00 | 0.071 |
a, *1a = wild type at all loci; b, *1b =rs2306283 G allele (A ancestral) (c.388A>G, p.N130D); c, *5 = rs4149056 Callele (T ancestral) (c.521T>C, p.V174A); d, *15 = rs2306283 G allele (A ancestral) and rs4149056 C allele (T ancestral).