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. 2020 Jun 5;14:141. doi: 10.3389/fncel.2020.00141

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Copyright © 2020 Nunez-Parra, Cea-Del Rio, Huntsman and Restrepo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cholinergic neurons (CNs) respond to trial start in the go/go–no (GNG) task. (A) Top and middle. Examples of responses for units classified as cholinergic. Top, raster plot of 15 trials aligned by trial start (orange dashed line, left) or conditioned stimulus (CS) presentation (right, light blue dashed line: water delivery or reward, bar 50 Hz). Middle, peristimulus time histogram (PSTH). Bottom, mean normalized firing rate (FR) for six identified CNs (increase: orange; decrease: green; no change: gray). Shaded area represents the SD of the mean. (B) Summary of CNs responses. Left, percent responding to tstart (66.7%), CS (83.3%), and reward (0%). Right, comparison of the CNs responses in all events.