Figure 3.

The median simulated plasma concentration-time profiles based on the final population PK model. (A) the creatinine clearance (CrCL) of 31.3 ml/min; (B) the CrCL of 105.9 ml/min; (C) the CrCL of 315.2 ml/min; the blue solid lines represented 100 mg loading dose with 50 mg maintenance dose twice daily; the red dash solid lines represented 150 mg loading dose with 75 mg maintenance dose twice daily; the black dot lines represented 150 mg loading dose with 100 mg maintenance dose twice daily.