Table 2.
Parameter estimates and bootstrap results of the final population pharmacokinetic model.
| Parameter | Final model | Bootstrap | ||||||
|---|---|---|---|---|---|---|---|---|
| Estimate | SE | CV (%) | Shrinkage (%) | Median | SE | CV(%) | 95% CI | |
| tvV | 6.218 | 0.83 | 13.33 | 12.31 | 5.960 | 0.92 | 15.50 | 4.169–8.090 |
| tvV2 | 11.922 | 1.74 | 14.62 | 0.66 | 12.073 | 1.71 | 14.17 | 8.705–15.960 |
| tvCl | 1.786 | 0.12 | 6.75 | 8.45 | 1.771 | 0.09 | 5.18 | 1.581–1.964 |
| tvQ | 13.518 | 3.35 | 24.82 | 17.57 | 14.427 | 3.68 | 25.50 | 8.157–23.928 |
| dCldCrCL | 0.362 | 0.09 | 24.82 | NA | 0.357 | 0.07 | 20.47 | 0.196–.513 |
| Inter-individual variability | ||||||||
| ω2V | 0.318 | 0.14 | 43.71 | NA | 0.354 | 0.14 | 39.27 | NA |
| ω2Cl | 0.208 | 0.04 | 21.15 | NA | 0.204 | 0.03 | 16.18 | NA |
| ω2V2 | 0.690 | 0.20 | 29.42 | NA | 0.660 | 0.19 | 28.94 | NA |
| ω2Q | 1.508 | 0.46 | 30.44 | NA | 1.458 | 0.45 | 31.48 | NA |
| CorrV-Cl | 0.713 | 0.06 | 8.13 | NA | 0.681 | 0.08 | 11.31 | NA |
| CorrV-V2 | 0.667 | 0.13 | 19.49 | NA | 0.630 | 0.12 | 19.84 | NA |
| CorrCl-V2 | 0.571 | 0.07 | 12.26 | NA | 0.578 | 0.06 | 10.03 | NA |
| Residual variability (σ) | ||||||||
| stdev0 | 0.110 | 0.01 | 5.30 | NA | 0.110 | 0.01 | 7.13 | 0.093–0.127 |
SE, standard error; CV%, percent confidence of variation; CI, confidence interval; tvV, typical value of volume of central compartment distribution (V); tvV2, typical value of volume of peripheral compartment distribution (V2); tvCl, typical value of central compartment clearance (Cl); tvQ, typical value of inter-compartmental clearance (Q, Cl2); dCldCrCL, fixed parameter coefficient of creatinine clearance (CrCL) to Cl; ωV, variance of inter-individual variability for V; CorrV-Cl, correlation between V and Cl; stdev0, standard deviation; NA, not applicable.