Table 5.
The linear regression analysis of AUC0–12h.
| Model | Time | Equation | r2 | PE range (%) | RMSE | ICC (95% Cl) | Limits of agreement (%) |
|---|---|---|---|---|---|---|---|
| 11 | C1h | Y=1.345+5.338×C1h | 0.747 | −36.59 to 104.66 | 32.15 | 0.858 (0.742–0.925) | −23.74 to 23.74 |
| 12 | C0h | Y=14.009+14.958×C0h | 0.803 | −41.95 to 79.78 | 27.13 | 0.894 (0.803–0.944) | −19.39 to 21.02 |
| 13 | C2h | Y = −2.099+8.763×C2h | 0.937 | −34.17 to 36.28 | 16.33 | 0.968 (0.938–0.984) | −12.22 to 12.22 |
| 14 | C4h | Y = 0.533 + 9.876×C4h | 0.962 | −29.91 to 33.13 | 13.07 | 0.981 (0.964–0.990) | −9.196 to 9.196 |
| 15 | C0h+C4h | Y = 1.608 + 4.574×C0h+7.602×C4h | 0.986 | −26.22 to 19.60 | 9.07 | 0.993 (0.987–0.996) | −5.558 to 5.558 |
| 16 | C0h+C2h | Y = −0.673+6.048×C0h+6.230×C2h | 0.989 | −19.18 to 18.80 | 8.50 | 0.995 (0.989–0.997) | −5.151 to 5.151 |
| 17 | C2h+C8h | Y = −0.274+4.761×C2h+7.181×C8h | 0.992 | −9.28 to 23.93 | 6.67 | 0.996 (0.992–0.998) | −4.405 to 4.405 |
| 18 | C1h+C4h+C8h | Y = 0.523 + 0.882×C1h+4.697×C4h+ 6.099×C8h | 0.997 | −8.08 to 16.68 | 4.43 | 0.999 (0.997–0.999) | −2.628 to 2.628 |
| 19 | C1.5h+C4h+C8h | Y = 0.599 + 1.964×C1.5h+3.169×C4h+6.633×C8h | 0.998 | −7.66 to 5.70 | 3.29 | 0.999 (0.998–1.0) | −2.295 to 2.295 |
| 20 | C1h+C1.5h+C4h+C8h | Y = 0.260 + 0.460×C1h+1.137×C1.5h+3.644×C4h+6.480×C8h | 0.999 | −3.83 to 4.33 | 2.40 | 1.0 (0.999–1.0) | −1.710 to 1.710 |
AUC0–12 h, the area under the concentration-time curve from 0 h to 12 h; PE, prediction error; RMSE, root mean square error; ICC, intraclass correlation coefficient.