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. 2020 Jun 5;10:879. doi: 10.3389/fonc.2020.00879

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Copyright © 2020 Hernandez Puente, Hsu, Rogers, Jousheghany, Siegel, Kadlubar, Beck, Makhoul, Hutchins, Kieber-Emmons and Monzavi-Karbassi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PCA plot and heatmap based on the 182 differentially methylated CpG loci (p ≤ 0.001) from the regression model considering IgG titers. (A) PCA scatter plot demonstrates separation according to the anti-peptide IgG levels. (B) Heatmap representing the similarities of DNA methylomes clustered according to their IgG levels (in fold change). The columns represent the CpG probes and rows the samples taken from indicated subjects. CpG probes with no changes in methylation have a value of zero and colored in black. Hypermethylated probes are displayed in red and hypomethylated probes in green. Subjects' study-numbers and fold increases in anti-peptide antibody titers are shown.