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. 2020 Jun 5;8:398. doi: 10.3389/fcell.2020.00398

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Copyright © 2020 Lei, Ehle, Kumar, Müller, Moll, Malone, Humphreys, Andrassy and Anders.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cat-S and PAR-2 gene expression in healthy and rejected human kidney biopsies by single-cell RNA-seq. (A) UMAP plots of combined correlation analysis of a mixed rejection kidney transplant biopsy and a healthy human kidney tissue sample. Left: cell clusters labeled by cell type. Right: clusters labeled according to rejection (blue) or healthy (red) kidney. (B) Violin plots of Cat-S (CTSS) and PAR-2 (F2RL1) gene expression per cell type, in rejection (green) and healthy (red). Upper: CTSS expression. Lower: F2RL1 expression. (C) Feature UMAP plots of Cat-S (left) and PAR2 (right) expression. Purple color demotes high gene expression.