Fig. 4.

Neonatal outcomes in advanced maternal aged dams. (a) Experimental design of data collection from the offspring of advanced maternal aged (AMA) and control dams. (b) Kaplan–Meier survival curves showing the rate of survival of offspring from AMA dams and controls at birth and 1, 2, and 3 weeks of life. The P‐values were determined by Mantel–Cox test. (c) Weights of the placentas from controls and AMA dams at 18·5 days post‐coitum (dpc). Weights of the offspring from control and AMA dams at (d) 18·5 dpc, (e) 1 week and (f) 3 weeks of age (n = 22–103 each). Data are shown as scatter‐plots mean with standard error of the mean (s.e.m.)]. The P‐values were determined by a Mann–Whitney U‐test. Significant P‐values are shown in bold type.