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. 2020 Jun 5;11:1017. doi: 10.3389/fimmu.2020.01017

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Copyright © 2020 Hirai, Yamaguchi-Tomikawa, Eguchi, Maeda and Takashiba.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Receiver operative characteristic (ROC) curve analysis to evaluate the diagnostic capacity of individual recombinant antigens (25N, 25C, 27N, and 27C) to distinguish between periodontitis patients and healthy individuals. (A) ROC curves were generated as described by Ekuseru-Toukei 2010 (Social Survey Research Information Co., Ltd.) using the spot intensities from the dot blot analysis (Figure 6). (B) The values of AUC with 95% confidence interval (CI) and sensitivity/specificity with optimal cut-offs are presented in the lower panel. N, N-terminal half; C, C-terminal half.