FIGURE 4.

Typical tumor registration examples for (A) glioblastoma and (B) lower-grade glioma. Axial slices with delineated pre- and post-operative tumor are shown in patient space (left), ICBM2009a space (middle) and after non-linear transformation by the DARTEL registration package (right). (A) A 66-year-old female with a 46.4 mL preoperative tumor and 3.8 mL postoperative tumor. Dice scores are 0.67 for preoperative tumor and 0.43 for postoperative tumor, and modified Hausdorff distances are 4.1 and 2.5 mm, respectively. (B) A 34-year old male with a 25 mL preoperative tumor and 12 mL postoperative tumor. Dice scores are 0.62 for pre-operative tumor and 0.55 for postoperative tumor, and modified Hausdorff distances are 4.5 and 4.2 mm, respectively.