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. 2020 Jun 5;10:884. doi: 10.3389/fonc.2020.00884

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Copyright © 2020 Abou, Benabdallah, Jiang, Peng, Zhang, Villmer, Longtine and Thorek.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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[⁶⁸Ga]PSMA-11 Imaging Response to [²²⁵Ac]PSMA-617. Alpha-particle emitting Ac-225 bound to the DOTA chelator-bearing PSMA-617 scaffold was used to treat a patient following disease progression after several lines of conventional treatment and [¹⁷⁷Lu]PSMA-617. Serial images during the treatment course reveal significantly less PSMA expression and potential lesion eradication. A decrease in salivary gland uptake is also noted, as it is a site of PSMA expression inadvertently treated by these agents. Reproduced from (71).