Figure 3.

Upregulation and downregulation of genes in SH-SY5Y cells infected with ZIKV^PR, ZIKV^MR, and DENV2. (A) Venn diagram of genes differentially expressed between infected SH-SY5Y cells that were differentially upregulated (top) or downregulated (bottom). DE transcripts from ZIKV^PR, ZIKV^MR, and DENV2 are within the respective red, blue, and yellow circles. (B) Heatmap of the top 50 statistically significant differentially expressed immune response genes in ZIKV^PR-infected cells compared to mock. The expression of these genes in ZIKV^MR and DENV2-infected SH-SY5Y cells is shown for comparison. Three replicates from each condition were collapsed and normalized to mock. The color scale shows the Z-score of the immune response genes.