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. 2020 May 7;11(5):520. doi: 10.3390/genes11050520

Figure 8.

Figure 8

Topology of gene networks is sensitive to the cellular environment. (a,b) Proximity of non-touching olineu remodels the transcriptomic networks by which expression of genes encoding connexin43 (Gja1) and pannexin1 (Panx1) relate to the expression of (a) actin cytoskeleton and (b) circadian rhythm genes in astrocytes. (c,d) Proximity of non-touching astrocytes changes the expression coordination of Panx1 with (c) circadian rhythm and (d) actin cytoskeleton genes in Oli-neu. Thicker continuous lines in (a) indicate reversal type of coordination in astrocyte by oligodendrocyte proximity. Dashed lines in (d) indicate opposite coordination in astrocytes and oli neu when co-cultured. CONTROL/OLI-AST = astrocytes/Oli-neu cells cultured alone. INSERT/OLI+AST = co-culture of astrocytes and Oli-neu cells. Note: in order to simplify the illustration, only the Panx1 coordination partners from the two pathways in astrocytes are presented in the Oli-neu cells.