Table 2.
Classification of phenotypes for different cellular processes for ATG5¯, ATG5¯/12¯ and ATG5¯/12¯/16¯ cells. “+” and “−“ indicate an increase and a decrease, respectively, in the corresponding activity in the mutants in comparison to AX2 cells. Multiple “+” and “−“ indicate the severity of the phenotype.
| Type | Cellular Process | Strains | ||
|---|---|---|---|---|
| ATG5¯ | ATG5¯/12¯ | ATG5¯/12¯/16¯ | ||
| (i) | Development | − | − | − |
| Cell viability | − | − | − | |
| Conjugation of ATG8 to PE | − | − | − | |
| (ii) | Generation time | − | −− | −−− |
| Macropinocytosis | − | − | −− | |
| Phagocytosis of yeast | − | − | −− | |
| (iii) | Growth on K. aerogenes | ++ | − | + |
| Phagocytosis/membrane association of bacteria | ++ | − | + | |
| (iv) | Proteasomal activity | −− | −− | − |