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. 2020 May 25;12(5):579. doi: 10.3390/v12050579

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The genome of Zika virus (ZIKV) and the CpG (cytosine–phosphate–guanine)-recoding strategy. ZIKV genomic regions encoding envelope (E) and non-structural 1 (NS1) proteins were recoded to increase the number of CpG dinucleotides. A barcode schematically represents the number of CpG dinucleotides. The actual number of CpG dinucleotides are in Supplementary Table S1.