Table 1.
Identified candidate proteins in hippocampal homogenates decreased after pyridoxine-deficient diet treatment more than two-folds. Note that only V-type proton ATPase subunit B2 (ATP6V1B2) shows more than 20 peptides matched in the identified protein and protein sequence coverage.
| Proteins (gI Accession Number) |
Number of Peptides Matched in the Identified Protein | Protein Sequence Coverage (%) | pI, Mr (kDa) | MOWSE | Fold Decrease |
|---|---|---|---|---|---|
| APG-1 (705391) |
1 | 1 | 5.53, 95.3 | 39 | |
| Zinc finger protein 831 (150010581) |
1 | 0 | 8.18 176.1 |
40 | 2.3 |
| Murine valosin-containing protein (55217) |
3 | 3 | 5.14 89.9 |
105 | 2.5 |
| Heat-shock protein hsp84 (194027) |
2 | 3 | 4.95 83.5 |
89 | 2.0 |
| V-type proton ATPase subunit B2 (17105370) |
38 | 25 | 5.57 56.9 |
638 | 2.3 |
| Vacuolar adenosine triphosphatase subunit B (1184661) |
1 | 2 | 5.57 56.9 |
45 | 3.1 |
| Acyltransferase (1129118) |
1 | 2 | 8.88 53.5 |
48 | 2.8 |
| Anti-DNA immunoglobulin light chain IgG (1870366) |
1 | 8 | 9.11 11.1 |
39 | 2.1 |
| Poly(rC)-binding protein 1 (6754994) |
1 | 2 | 6.66 38.0 |
40 | 2.2 |
| Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (6680045) |
12 | 12 | 5.60 38.2 |
243 | 8.8 |
| Glyceraldehyde-3-phosphate dehydrogenase (2494630) |
1 | 1 | 8.14 48.4 |
34 | 3.0 |
| Charged multivesicular body protein 4b (2807749) |
2 | 11 | 4.76 24.9 |
85 | 2.1 |
| Voltage-dependent anion-selective channel protein 2 (6755965) |
3 | 7 | 7.44 32.3 |
102 | 3.4 |
| Serine-threonine kinase receptor-associated protein (4063383) |
1 | 3 | 4.99 38.8 |
36 | 2.8 |
| Osmotic stress protein 94 (1098541) |
5 | 5 | 5.50 95.2 |
215 | 3.3 |