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A prototypical virological synapse. The infected cell (CD4+ T cell or macrophage) forms a transient adhesive contact with a receptor-expressing target cell via Env-CD4 interactions (CD4+ T cell-T cell synapses) or via adhesion molecule interactions (macrophage-CD4+ T cell synapse). Virus buds from the infected cell and migrates towards receptors clustered on the target cells (arrow). Infection follows via conventional receptor-mediated entry.
