Table 3.

Comparison of examined redox parameters in chronic granulomatous disease (CGD) patients with CYBB and NCF1 mutations.

Parameter	CYBB, n = 5	NCF1, n = 10	p-Values
TAS, µmol/L	6.6 ± 1.8	8.5 ± 3.1	ns
TOS, µmol/L	10.6 ± 4.1	11.6 ± 2.3	ns
OSI	1.6 ± 0.7	1.5 ± 0.4	ns
CAT, nmol/100 mg of protein	6.2 ± 1.9	5.8 ± 1.9	ns
SOD, mU/mg	1.1 ± 0.2	1.1 ± 0.5	ns
GP, mU/100 mg protein	0.1± 0.01	0.1 ± 0,02	ns
UA, µg/100 mg of protein	0.8 ± 0.2	0.7 ± 0.2	ns
Coenzyme Q10, μg/mL	0.08 ± 0.04	0.05 ± 0.05	ns
Retinol, μg/mL	0.1 ± 0.09	0.08 ± 0.07	ns
Tocopherol, μg/mL	1.9 ± 1.1	1.6 ± 0.86	ns
8-OHdG, pg/mg of protein	18.0 ± 28.7	24.7 ± 19.8	ns
AOPP, nmol/mg protein	4.1 ± 1.5	4.5 ± 2	ns
4-HNE, µg/mg protein	0.17 ± 0.14	0.19 ± 0.06	ns
8-isoP, pg/mg protein	0.9 ± 0.2	0.8 ± 0.2	ns
AGE, fluorescence/mg protein	500.2 ± 168.8	443 ± 153	ns

CYBB, gp91 phox; NCF1, gp47phox. TOS, total oxidant status; TAS, total antioxidant status; OSI, oxidative stress index; CAT, catalase; SOD, superoxide dismutase; GPx, glutathione peroxidase; UA, uric acid; 8-OHdG, 8-hydroxy-D-guanosine; AOPP, advanced oxidation protein products; 4-HNE, 4-hydroxynonenal; 8-isoP, 8-isoprostanes; AGE, advanced glycation end products.