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. 2020 May;8(9):577. doi: 10.21037/atm-20-918

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2020 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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The bioenergetics profile of Tregs and CD4⁺CD25⁻ T cells from HC and MG patients. Tregs and CD4⁺CD25⁻ T cells from HCs and MG patients were compared for (A,C) mitochondrial stress profiles with injections oligomycin (2 µM), FCCP (1 µM) and antimycin A/rotenone (both 0.5 µM). (B,D) Glycolysis stress profiles with injections glucose (10 mM), oligomycin (3 µM) and 2-DG (50 mM). Glycolytic parameters of Tregs (E) and CD4⁺CD25⁻ T cells (F) from HC and MG patients (n=6). Statistical differences are reported in the text. *, P<0.05; **, P<0.01. HC, healthy controls; MG, myasthenia gravis.