Figure 1.

Differentially expressed miRNAs in human endothelial and vascular smooth muscle cells after treatment with oxidized low-density lipoproteins. miRNA expression was measured with microarrays in RNA extracted from cells (obtained from three individuals without cardiovascular disease) treated with native, moderately oxidized or highly oxidized low-density lipoproteins (nLDL, moxLDL, or hoxLDL, respectively). Differential expression of miRNAs was examined with moderated t-tests. Only the differentially expressed miRNAs in at least one cell type which expression followed a linear or quadratic trend between nLDL, moxLDL, and hoxLDL conditions are shown. p-values were not adjusted for multiple comparisons. Expression values are presented in Table S5. Log2 (fold change): binary logarithm of the fold change.