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. 2020 May;8(10):641. doi: 10.21037/atm-20-3323

Figure 1.

Figure 1

AT mitigated HI-induced brain neurons damage and apoptosis. Mice were randomly divided into the 7 following groups with 10 mice in each group: the control group, healthy rats; the HIBD group, hypoxic-ischemic brain damage models; the HIBD + AT (10 mg) group, the HIBD models given 10 mg/kg AT; the HIBD + AT (20 mg) group, HIBD models given mg/kg AT; the HIBD + AT (40 mg) group, HIBD models given mg/kg AT. (A) HE staining showed the histological changes in each group. (B) TUNEL staining showed the apoptosis in each group. The bar graph represents the percentage of apoptotic cells. (C) The expression of apoptosis marker proteins caspase-3 and caspase-9 in each group were measured by Western blot. The bar graph represents the relative protein expression level. Each experiment included 4 repetitions per condition (**, P<0.01 vs. control group; ##, P<0.01 vs. HIBD group). AT, asiaticoside; HIBD, hypoxic-ischemic brain damage; TUNEL, terminal-deoxynucleoitidyl transferase nick end labeling.