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. 2020 May;8(10):647. doi: 10.21037/atm-20-3768

Figure 6.

Figure 6

BC activates AGE-induced inhibition of the PI3K/Akt/mTOR signaling pathway. H9c2 cells were pre-treated with BC (40 µM) and then stimulated with AGEs (200 µg/mL) for 24 h. (A) The expressions of p-PI3K, p-AKT and p-mTOR were detected by Western blot. (B,C,D) Semi-quantitative analysis of the relative levels ofp-PI3K, p-AKT, and p-mTOR. Each experiment was repeated in triplicate. *, P<0.05 vs. control group; #, P<0.05 vs. AGE-induced group. BC, beta-carotene; AGEs, advanced glycation end products; PI3K/Akt/mTOR, Phosphatidyl inositol 3-kinase/Akt/ mammalian target of rapamycin; p-PI3K, phosphorylated PI3K; p-AKT, phosphorylated Akt; p-mTOR, phosphorylated mTOR.