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. 2020 May;8(10):646. doi: 10.21037/atm-20-3079

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2020 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Reduced AURKB expression suppressed the proliferation induced by ALKBH5 in RCC cells. (A,B) CCK8 and clone formation assays were used to measure the effect of AURKB small interference RNA (siAURKB) on Caki-1 and 786-0 cells with ALKBH5 overexpression. (C,D) The effect of AURKB inhibitor (AZD1152-HQPZ and hesperidin) on Caki-1 and 786-0 cells with ALKBH5 overexpression was measured by CCK8 and clone formation assays. The colony fold (NC/ALKBH5) is stated under the histogram. Data are presented as mean ± SD. *, P<0.05; ^#, P<0.05. RCC, renal cell carcinoma.