Table S2. GRADE evidence profile.
| No. of studies | Sample size | Certainty assessment | Effect value (95% CI) | Certainty | ||||
|---|---|---|---|---|---|---|---|---|
| Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | ||||
| Serum globulin | ||||||||
| RCT (31) | 44 | Serious1 | Not applicable | Serious2 | Not serious | None | MD 6.00 (4.75 to 7.25) | ⨁⨁◯◯ low |
| Nosocomial infection rate | ||||||||
| RCT (31) | 44 | Serious1 | Not applicable | Serious | Not serious | None | OR 1.25 (0.47 to 3.31) | ⨁⨁◯◯ low |
| The risk of death | ||||||||
| RCT (31) | 44 | Serious1 | Not applicable | Serious | Not serious | None | OR 1.70 (0.51 to 0.73) | ⨁⨁◯◯ low |
Explanations: 1, unclear risk of bias in allocation concealment, random sequence generation and blinding; 2, using other drugs (such as interferon, hormone, etc.) before intervention. CI, confidence interval; OR, odds ratio; MD, mean deviation.