Table 3. Multivariate Cox proportional hazards model for second primary malignancy.
| Variables | Subtype | All | Male | Female | |||||
|---|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | ||||
| Primary site of FPM | Bladder | ref | ref | ref | ref | ref | ref | ||
| Brain, CNS | 1.17 (1.03–1.31) | 0.029 | 1.30 (1.13–1.48) | 0.003 | 0.97 (0.75–1.21) | 0.810 | |||
| Cervix uteri | 1.13 (1.04–1.21) | 0.006 | – | – | 1.13 (1.04–1.23) | 0.017 | |||
| Colorectal | 0.96 (0.93–1.00) | 0.029 | 0.97 (0.93–1.01) | 0.193 | 0.94 (0.88–1.00) | 0.070 | |||
| Corpus uteri | 0.98 (0.93–1.04) | 0.537 | – | – | 0.97 (0.90–1.05) | 0.404 | |||
| Esophagus | 1.12 (1.02–1.21) | 0.021 | 1.07 (0.96–1.17) | 0.238 | 1.38 (1.18–1.60) | 0.003 | |||
| Female breast | 0.92 (0.88–0.96) | <0.001 | – | – | 0.91 (0.85–0.97) | 0.004 | |||
| Kidney | 0.97 (0.93–1.02) | 0.263 | 0.97 (0.91–1.02) | 0.239 | 0.97 (0.88–1.07) | 0.503 | |||
| Liver | 1.64 (1.54–1.75) | <0.001 | 1.67 (1.55–1.80) | <0.001 | 1.58 (1.36–1.82) | <0.001 | |||
| Lung and bronchus | 1.14 (1.1.0–1.18) | <0.001 | 1.15 (1.10–1.20) | <0.001 | 1.11 (1.04–1.19) | 0.011 | |||
| NHL | 1.04 (1.00–1.08) | 0.059 | 1.04 (0.99–1.09) | 0.172 | 1.04 (0.97–1.12) | 0.297 | |||
| Ovary | 1.09 (1.00–1.17) | 0.047 | – | – | 1.06 (0.97–1.16) | 0.204 | |||
| Pancreas | 1.36 (1.24–1.48) | <0.001 | 1.43 (1.28–1.59) | <0.001 | 1.27 (1.10–1.45) | 0.009 | |||
| Prostate | 0.94 (0.90–0.97) | <0.001 | 0.94 (0.91–0.97) | <0.001 | – | – | |||
| Stomach | 1.08 (1.01–1.16) | 0.042 | 1.11 (1.02–1.21) | 0.031 | 1.03 (0.90–1.17) | 0.700 | |||
| Thyroid | 1.02 (0.95–1.09) | 0.574 | 1.05 (0.94–1.16) | 0.379 | 0.99 (0.90–1.09) | 0.918 | |||
| Primary site of SPM | Bladder | 0.45 (0.38–0.52) | <0.001 | 0.43 (0.34–0.51) | <0.001 | 0.52 (0.39–0.66) | <0.001 | ||
| Brain, CNS | ref | ref | ref | ref | ref | ref | |||
| Colorectal | 0.37 (0.30–0.44) | <0.001 | 0.36 (0.28–0.45) | <0.001 | 0.39 (0.28–0.51) | <0.001 | |||
| Esophagus | 0.61 (0.53–0.69) | <0.001 | 0.59 (0.50–0.69) | <0.001 | 0.65 (0.50–0.81) | <0.001 | |||
| Female breast | 0.31 (0.24–0.39) | <0.001 | – | – | 0.33 (0.22–0.45) | <0.001 | |||
| Female genital system | 0.35 (0.28–0.42) | <0.001 | – | – | 0.36 (0.25–0.48) | <0.001 | |||
| Kidney | 0.38 (0.30–0.45) | <0.001 | 0.36 (0.27–0.46) | <0.001 | 0.41 (0.28–0.55) | <0.001 | |||
| Leukemia | 0.37 (0.30–0.45) | <0.001 | 0.35 (0.26–0.45) | <0.001 | 0.41 (0.30–0.53) | <0.001 | |||
| Liver | 0.76 (0.68–0.84) | <0.001 | 0.77 (0.67–0.87) | <0.001 | 0.70 (0.55–0.86) | <0.001 | |||
| Lung and bronchus | 0.53 (0.47–0.59) | <0.001 | 0.54 (0.46–0.61) | <0.001 | 0.51 (0.42–0.61) | <0.001 | |||
| Melanoma of skin | 0.30 (0.23–0.38) | <0.001 | 0.31 (0.22–0.40) | <0.001 | 0.29 (0.16–0.43) | <0.001 | |||
| NHL | 0.29 (0.21–0.36) | <0.001 | 0.27 (0.18–0.36) | <0.001 | 0.32 (0.21–0.44) | <0.001 | |||
| Other | 0.39 (0.32–0.45) | <0.001 | 0.37 (0.29–0.45) | <0.001 | 0.42 (0.31–0.54) | <0.001 | |||
| Pancreas | 0.81 (0.74–0.88) | <0.001 | 0.79 (0.71–0.88) | <0.001 | 0.84 (0.73–0.96) | 0.003 | |||
| Prostate | 0.28 (0.21–0.36) | <0.001 | 0.28 (0.19–0.36) | <0.001 | – | – | |||
| Stomach | 0.57 (0.49–0.64) | <0.001 | 0.54 (0.45–0.63) | <0.001 | 0.62 (0.49–0.76) | <0.001 | |||
| Thyroid | 0.30 (0.19–0.41) | <0.001 | 0.31 (0.15–0.47) | <0.001 | 0.29 (0.14–0.45) | <0.001 | |||
| Age group, yrs | 18–34 | ref | ref | ref | ref | ref | ref | ||
| 35–49 | 0.89 (0.70–1.09) | 0.264 | 0.94 (0.58–1.30) | 0.739 | 0.88 (0.66–1.12) | 0.264 | |||
| 50–64 | 1.01 (0.82–1.20) | 0.929 | 1.01 (0.66–1.36) | 0.942 | 1.01 (0.79–1.25) | 0.911 | |||
| 65–79 | 1.10 (0.91–1.29) | 0.304 | 1.11 (0.76–1.46) | 0.568 | 1.11 (0.89–1.35) | 0.376 | |||
| 80+ | 1.37 (1.18–1.56) | 0.001 | 1.36 (1.01–1.71) | 0.083 | 1.38 (1.16–1.62) | 0.006 | |||
| Gender | Female | ref | ref | – | – | – | – | ||
| Male | 1.02 (0.99–1.05) | 0.142 | – | – | – | – | |||
| Race | American Indian/Alaska Native | ref | ref | ref | ref | ref | ref | ||
| Asian or Pacific Islander | 0.95 (0.81–1.10) | 0.506 | 0.86 (0.67–1.04) | 0.101 | 1.10 (0.88–1.34) | 0.435 | |||
| Black | 0.96 (0.82–1.11) | 0.622 | 0.85 (0.67–1.04) | 0.092 | 1.13 (0.93–1.35) | 0.271 | |||
| Unknown | 1.87 (0.98–2.75) | 0.168 | 1.55 (0.41–2.70) | 0.452 | 2.54 (1.2–3.95) | 0.193 | |||
| White | 0.90 (0.76–1.04) | 0.140 | 0.80 (0.62–0.98) | 0.018 | 1.04 (0.84–1.26) | 0.701 | |||
| Year of diagnosis of events | 2000–2003 | ref | ref | ref | ref | ref | ref | ||
| 2004–2007 | 0.50 (0.45–0.54) | <0.001 | 0.48 (0.42–0.54) | <0.001 | 0.53 (0.46–0.61) | <0.001 | |||
| 2008–2010 | 0.30 (0.25–0.35) | <0.001 | 0.29 (0.23–0.35) | <0.001 | 0.32 (0.25–0.40) | <0.001 | |||
| 2011–2013 | 0.20 (0.15–0.25) | <0.001 | 0.19 (0.13–0.25) | <0.001 | 0.22 (0.15–0.30) | <0.001 | |||
| Month Since Index, months | 13–26 | ref | ref | ref | ref | ref | ref | ||
| 27–44 | 1.15 (1.13–1.17) | <0.001 | 1.18 (1.15–1.21) | <0.001 | 1.11 (1.07–1.15) | <0.001 | |||
| 45–71 | 1.45 (1.43–1.47) | <0.001 | 1.48 (1.45–1.51) | <0.001 | 1.41 (1.37–1.45) | <0.001 | |||
| 72+ | 2.31 (2.29–2.34) | <0.001 | 2.39 (2.35–2.42) | <0.001 | 2.21 (2.17–2.25) | <0.001 | |||
| Stage | In situ | 0.37 (0.31–0.44) | <0.001 | 0.37 (0.29–0.45) | <0.001 | 0.36 (0.21–0.52) | <0.001 | ||
| Localized | 0.49 (0.47–0.52) | <0.001 | 0.48 (0.45–0.51) | <0.001 | 0.52 (0.48–0.56) | <0.001 | |||
| Regional | 0.61 (0.58–0.63) | <0.001 | 0.58 (0.55–0.61) | <0.001 | 0.64 (0.60–0.68) | <0.001 | |||
| Distant | ref | ref | ref | ref | ref | ref | |||
| Unknown/unstaged | 0.82 (0.79–0.84) | <0.001 | 0.78 (0.74–0.81) | <0.001 | 0.89 (0.85–0.93) | <0.001 | |||
| Grade | Grade I | 0.89 (0.85–0.93) | <0.001 | 0.88 (0.83–0.94) | <0.001 | 0.91 (0.85–0.97) | 0.003 | ||
| Grade II | ref | ref | ref | <0.001 | ref | ref | |||
| Grade III | 1.20 (1.17–1.22) | <0.001 | 1.18 (1.15–1.21) | <0.001 | 1.23 (1.19–1.27) | <0.001 | |||
| Grade IV | 1.28 (1.24–1.32) | <0.001 | 1.30 (1.25–1.35) | <0.001 | 1.25 (1.19–1.31) | <0.001 | |||
| Unknown | 1.25 (1.23–1.28) | <0.001 | 1.23 (1.20–1.26) | <0.001 | 1.29 (1.25–1.33) | <0.001 | |||
| %, bachelors degree, quartile | 1st | ref | ref | ref | ref | ref | ref | ||
| 2nd | 0.97 (0.95–0.99) | 0.014 | 0.97 (0.94–1.00) | 0.029 | 0.98 (0.94–1.02) | 0.237 | |||
| 3rd | 0.97 (0.94–1.00) | 0.026 | 0.97 (0.94–1.01) | 0.090 | 0.97 (0.93–1.01) | 0.167 | |||
| 4th | 0.97 (0.94–1.00) | 0.091 | 0.96 (0.92–1.00) | 0.048 | 0.99 (0.93–1.05) | 0.614 | |||
| Median household income, quartile | 1st | ref | ref | ref | ref | ref | ref | ||
| 2nd | 0.95 (0.93–0.98) | <0.001 | 0.96 (0.93–0.99) | 0.013 | 0.95 (0.91–0.99) | 0.007 | |||
| 3rd | 0.94 (0.92–0.97) | <0.001 | 0.93 (0.90–0.97) | <0.001 | 0.96 (0.92–1.00) | 0.073 | |||
| 4th | 0.91 (0.88–0.94) | <0.001 | 0.91 (0.87–0.95) | <0.001 | 0.91 (0.85–0.97) | 0.003 | |||