Table 5.
Follow-up cytokine levels according to the anti -tRNA autoantibodies in the complete cohort.
| Variable | Anti-Jo1+ Patients n = 10 |
Anti-PL7+ Patients n = 8 |
Anti-PL12+ Patients n = 11 |
Anti-EJ+ Patients n = 10 |
p-Value | ILD anti tRNA Positive Patients n = 39 |
|---|---|---|---|---|---|---|
| IL-1β | 92 (70–225) | 235 (187–405) | 224 (214–234) | 223 (104–233) | 0.05 * | 264 (88–324) |
| IL-2 | 256 (223-272) | 279 (238–479) | 276 (264–561) | 268 (266–273) | 0.19 | 271 (249–288) |
| IL-4 | 594 (288–786) | 754 (471–2595) | 691 (660–803) | 709 (528–744) | 0.60 | 698 (472–803) |
| IL-5 | 357 (235–445) | 443 (440–1722) | 438 (428–476) | 437 (313–442) | 0.09 | 438 (337–447) |
| IL-6 | 650 (435–2308) | 2339 (2127–5185) | 2298 (1709–2349) | 2313 (430–2359) | 0.38 | 2298 (456–2358) |
| IL-9 | 441 (357–558) | 512 (3893–1871) | 551 (536–622) | 505 (398–548) | 0.39 | 534 (398–593) |
| IL-10 | 64 (61–75) | 129 (73–235) | 69 (66–84) | 72 (68–80) | 0.12 | 71 (63–89) |
| IL-12 p70 | 322 (296–328) | 308 (278–435) | 298 (275–351) | 296 (284–342) | 0.90 | 305 (283–344) |
| IL-13 | 111 (97–143) | 123 (99–518) | 102 (72–211) | 306 (283–345) | 0.76 | 109 (97–172) |
| IL-17A | 279 (220–286) | 288 (152–477) | 225 (140–287) | 125 (124–143) | 0.13 | 225 (126–290) |
| IL-18 | 1128 (672–1535) | 1231 (845–2653) | 1108 (1039–1504) | 1050 (831–1260) | 0.82 | 1064 (878–1535) |
| IL-21 | 526 (131–959) | 583 (341–4368) | 327 (281–495) | 331 (297–740) | 0.18 | 345 (297–765) |
| IL-22 | 1408 (729–2025) | 1298 (1032–2698) | 1058 (786–3174) | 1045 (949–2017) | 0.81 | 1062 (870–2262) |
| IL-23 | 923 (900–945) | 1033 (915–3631) | 932 (922–956) | 929 (910–939) | 0.44 | 932 (908–1065) |
| IL-27 | 475 (457–489) | 477 (462–1742) | 481 (475–2359) | 481 (470–6790) | 0.60 | 479 (461–1650) |
| INF-γ | 786 (631–843) | 1042 (760–1391) | 843 (691–991) | 713 (669–738) | 0.14 | 815 (669–932) |
| GM-CSF | 855 (679–856) | 2084 (765–3786) | 710 (691–856) | 716 (689–856) | 0.28 | 855 (689–856) |
| TNF-α | 380 (309–407) | 406 (377–1259) | 405 (403–410) | 408 (404–409) | 0.33 | 406 (359–409) |
The units of the serum cytokine concentrations were pg/mL in all cases. All values are expressed as medians (IQR). * After the correction of Bonferroni, no significant differences were observed in any group in the serum concentration of IL-1β.