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Progressive accumulation of p62 aggregates in the brain of twitcher mice. Distribution of p62 aggregates in different regions of the twitcher (Twi) brain at ages 21 to 42 days. The twitcher brain and wild-type (WT) brain were immuno-stained with anti-p62 (in green) and anti-PLP (in red), respectively, and nuclei were counterstained with DAPI (in blue). Scale bars: 200 μm.
