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. 2020 May 6;12(5):514. doi: 10.3390/v12050514

Figure 1.

Figure 1

Serum IgG responses elicited in mice immunized with type 2 Dengue virus particles (DENV2) through transcutaneous (TC) or intradermal (ID) administration routes. Concentrated virus particles (10 or 50 µg protein/dose) were administered alone or with heat-labile toxin (LT) as adjuvant (10 µg/dose) in BALB/c mice (n = 5). The immunization protocol consisted of 3 doses administered with a two week interval. Both TC as well as ID inoculations were administered in the dorsum of the animals, as described in the Material and Methods section. (A,B) Dose-dependent anti-DENV serum IgG responses elicited in mice following administration via TC (A) or ID (B) routes. Columns represent mean IgG concentration values + SD. (C,D) Individual serum anti-DENV2 IgG responses in mice submitted to TC (C) or ID (D) immunizations measured two weeks after the last dose. Statistical analysis was performed with a two-way ANOVA test associated with Bonferroni’s post-test. * p < 0.05, ** p < 0.01, *** p < 0.001. Representative results of 3 independent experiments.