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. 2020 Apr 28;9(5):1091. doi: 10.3390/cells9051091

Table 1.

Microbes produce various metabolites that influence multiple biological functions.

Biological Process Microbial Species Reference
Carbohydrate metabolism
Parent carbohydrate Metabolite
Most gut organisms
Eubacterium hallii
Roseburia
Coprococcus catus
Megasphera elsdenii
Veillonella spp
Ruminococcus obeum
Bacteroidetes
Eubacterium rectale
Eubacterium hallii
Roseburia spp
Coprococcus spp
Faecalibacterium prausnitzii
Bifidobacterium spp
Lactobacillus spp
Methanobrevibacter smithii
Desulfovibrio spp

[159,161,163,168]
[22]
Polysaccharides
Oligosaccharides
Resistant starch
Mucins
Acetate
Propionate

Butyrate
Lactate
CH4
H2S
Fat metabolism
Eubacterium siraeum
Roseburia faecis
Roseburia intestinalis
F. prausnitzii
Bifidobacterium
Propionibacterium
Lactobacillus spp
Bifidobacterium breve
Propionibacterium freudenreichii
Roseburia inulinivorans
Roseburia hominis
Butyrivibrio fibrisolvens
Clostridia Peptostreptococci
Peptococci

[27]

Linoleic acid
Conjugated lineloic acids

Stearic acid
Fatty acids
Short chain fatty acids(SCFA)
Branched chain fatty acid(BCFA)
(Isobutyrate from valine; 2-methylbutyrate from isoleucine; Isovalerate from leucine)
Protein metabolism Akkermansia
Bifidobacterium
[166,172]
Bile metabolism Cholic acid
Chenodeoxycholic acid
Deoxycholic acid
Lithocholic acid
Ursodeoxycholic acid

Bacteroides
Bifidobacterium
Clostridium
Lactobacillus
Listeria
Clostridium
Eubacterium
Bacteroides
Clostridium
Egghertella
Peptostreptococcus
Ruminococcus
Eubacterium

[170]
Vitamin synthesis Biotin
Cobalamin
Folate
Nicotinic acid
Panthothenic acid
Pyridoxine
Riboflavin
Thiamine
Bacteroidetes (Most important)
Fusobacteria
Proteobacteria
Firmicutes
Actinobacteria
[165,166]
Phytochemical metabolism
Phytochemical
Flavonoids
Lignans
Ferulic acid
Isofllavones
Caretenoids
Glucosinolates
Isothiocyanates
Stilbens
Organosulfur compounds
Process
Deglycosylation
Ring fission
Dehydroxylation

Clostridium spp.
Eubacterium ramulus
Lactobacillus mucosae
Enterococcus faecium
Finegoldia magna
Veillonella sp
Slakia isoflavoniconvertens
Slakia equolifaciens
Adlercreutzia equolifaciens

[166,171,173]
Antibiotics
Staphylococcus lugdunensis
Pantoea agglomerans
P. Vagans
Clostridium sp.
[172,173]
Lugdunin
Herbicolin I
Andrimid
Polykitide synthase
Bacteriocins Lactococcus lactis
Butyrivibrio fibrisolvens
Pedicoccus acidilactici
Lactobacillus sakei
Lactobacillus acidophillus
Enterococcus faecium
Lactobacillus helveticus
Enterococcus sp.
Lactobacillus plantarum
[85,174,175]
Nicin
Lacticin 3147
Butyrivibriocin
Pediocin
Sakacin A
Lactacin F
Lactococcin G
Enterolysin
Helvecticin I
Enterocin I F4-9
Glycocin F